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These findings suggest a pro-inflammatory condition and a preference towards the Th1 subtype of CD4 T-cells in sarcoidosis patients, with Th1 cells classically activating M1 macrophages

Lan N, Lu Y, Zhang Y, Pu S, Xi H, Nie X, Liu J, Yuan W (2020) FTO A Common Genetic Basis for Obesity and Cancer
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This suppression downregulates downstream inflammatory pathways, particularly those mediated by NF-B and MAPK kinases, leading to a reduction in pro-inflammatory cytokines such as IL-6 (83, 84)
