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Show signs of canine cognitive dysfunction: disorientation, disrupted sleep cycles, reduced interaction with family, behavioral changes without obvious cause

Like Semax, it was developed in Russia and has been used clinically, primarily for anxiety and cognitive enhancement

The inhibition potency of AUF on GSTP1 wild-type and cysteine mutants was similar, which suggested that unlike other inhibitors, GSTP1 inactivation by AUF is not related to cysteine residue binding

Nevertheless, their clinical application is still constrained by insufficient stability within the biological environment, restricted cellular uptake, and suboptimal pharmacokinetic profiles