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PMID: 28210123

The first one is synthesized through three steps, starting with the conversion of nicotinic acid into NAD, utilizing nicotinic acid mononucleotide and nicotinic acid adenine dinucleotide, while the second one is achieved by the action of enzyme NAD+ kinase, which phosphorylates NAD (, , )

However, drug efflux can be reduced through the use of BCRP inhibitors, such as gefitinib, a TKI that blocks BCRP transporter function, restoring drug sensitivity (263)