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Although its etiopathogenesis has yet to be fully explained, PD is known to affect males who have a genetic susceptibility, and it seems to be triggered by trauma, which may be mild or severe and is variously associated with risk factors, such as diabetes, chronic prostatitis, autoimmune disorders, hypertension, etc

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Kinetic experiments in the presence of -butyrobetaine revealed a high activity of 2.1 0.2 mol min 1 mg 1 which is in agreement with a recently published structural investigation (Quareshy et al., 2020)