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And phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) signal transduction pathways are also likely to regulate FASN expression (63, 64)
Theoretically, the intracellular assimilation of folic acid via dihydrofolate reductase might enhance thymidylate synthetase by bypassing the methylfolate trap, thereby allowing cellular proliferation to progress temporarily
