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In the quest for electronic stability, free radicals attack other molecules to stabilize their electronic state and thereby alter chemical structures and disrupt biomolecular functions [50, 118]

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The cytoplasm of RPE cells decreases in volume [4], and the cells become progressively vacuolated and pleiomorphic with respect to size, shape, nuclei, and pigmentation [4,75]

10.1186/s12889-023-15874-7 9
