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Evidence Quality Comparison# Side Effect and Safety Comparison# Dihexa Safety Considerations# The primary safety concern for Dihexa is specific to its mechanism

During nitrogen starvation, the total NAD + -GDH aminating activity tended to increase (a 14% increase between 0.5 and 1 hrs, p = 0.00, Table 1) and remained elevated but relatively constant throughout the ammonium starvation time course study (Table 1), presumably in order to assist nitrogen assimilation under these conditions

Statistical analysis For animal studies, sample sizes ( n = 5 per group, 3 in the tirzepatide-treated group) were determined based on prior in-house experience and previous studies using similar mouse models to ensure adequate power to detect biologically relevant effects