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Depade), prevents the reinforcing effects of alcohol by interfering with its enhancement of the mesolimbic DA transmission [111] strengthening the potential of caffeine, and more specifically of A2 A R antagonists, for future development of preventive/therapeutic strategies for AUD

Interestingly, mediation analysis showed that TMAOs adverse effect on kidney function strengthened at more severe stages of cardiometabolic disease, implying TMAO synergy with existing pathology (thereby providing 2-hit model)

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