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Investigations have revealed that the orphan nuclear receptor NR4A1 is pivotal in mediating metformins protective effects against endothelial dysfunction induced by high glucose levels

In addition, they may be associated with less post-operative pain and may result in less analgesic use and better cosmetic appearance than other types of cholecystectomy (Borchert 2017

doi: 10.1016/j.lfs.2004.08.015 258 MeropolNJSchulmanKA

Although this etiological mechanism has not been validated in patients, the symptoms of these AGR2-associated diseases are thus linked to the loss of PDI activity and the resulting mucin insufficiency, with presumptive effects on mucous barrier integrity in vital organs
