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Urine assays were for levels of creatinine, dopamine (DA), NA, AD, and two of their metabolites [homovanillic acid (HVA), MHMA] as well as the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the oxidative stress biomarker HPL

Magnesium also functions as a cation in maintaining cation-anion balance and as an osmotically active ion in cell turgor regulation (Marschner, 2012)

It should be noted that, however, the Epiderm we adopted for the present study is a commercially available human epidermal equivalent, which effectively provides a non-animal means to assess dermal toxicology and skin research issues 48

Fluctuations in SHBG concentrationsmodulated by metabolic status, insulin levels, and hepatic functioncan therefore influence the proportion of free E2 available for receptor activation, adding an additional regulatory layer to phase-dependent hormonal effects [28,29]