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Bioinorganic Chemistry and Applications, 2022 (1), Article 6341298
This manuscript summarizes potential biomarkers and therapeutic targets, based on available preclinical and clinical evidence, for better management of PD
Reduction of roGFP2-SG by GSH is the rate limiting step which is accelerated by GRXs, with its reactive cysteine attacking the disulfide of roGFP2-SG, resulting in glutathionylated GRX (GRX-SG) and roGFP2
Unlike IGF-1 LR3, which has a long half-life (2030 hours) and systemic activity, IGF-DES has a significantly shorter half-life (2030 minutes) but an intense localized effect
