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Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism

Cisplatin is a platinum-based chemotherapy drug that was approved by the FDA in 1978 despite its harsh side effects of inducing organ damage (including the liver and kidneys) [299], through oxidative metabolism via CYP2E1 and CYP4A11 [300]

Annually, approximately two million deaths worldwide are attributed to liver diseases, with one million resulting from cirrhosis and another one million due to viral hepatitis and hepatocellular carcinoma (HCC) (GBD, 2017 Cirrhosis Collaborators, 2020)

The induction of ferroptosis by impairing STAT3/Nrf2/GPx4 signaling enhances the sensitivity of osteosarcoma cells to cisplatin