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A stable cell cycle arrest and resistance to apoptosis are other phenotypes of cellular senescence

Thus, future studies need to identify the genes responsible for GSH biosynthesis and the cellular mechanisms underlying the regulation of enzymes related to GSH metabolism or degradation

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DNA lesions were detected by adding the chemiluminescence reagent Luminata western HRP substrate (Millipore), and using ImageQuant 300 (GE Healthcare, Little Chalfont, Buckinghamshire, UK)