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Description
Weight regain after discontinuation is well documented, with studies showing that most patients regain 50 to 70 percent of lost weight within 12 months of stopping treatment
Further, PEGylation of these NPs further prolongs their circulation time in the bloodstream, reducing protein interactions and enhancing their therapeutic efficacy (154)
60 (5): e341-4
GPX7/8 contain a KDEL ER localization sequence, making them ER-specific ROS scavengers
