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Well-funded, rigorously designed clinical trials to prove their efficacy and safety are a prerequisite for the translation of NCs into viable, evidence-based components of future ovarian cancer management
In further support of the KRAS G13D -specific HER2-HER3 dependence, GSEA of both our RNA-seq data and GSE39582 dataset revealed strong positive enrichment of the PI3K/AKT signaling pathway signature in HER2 high KRAS G13D cases, with notably elevated NES values (Supplementary Fig
The intestinal effect of atorvastatin: akkermansia muciniphila and barrier function
however, alterations in protein oxidation state can alter the subcellular localization and function of proteins (45, 147, 266, 316)
