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Additional pharmacological characterization by our group corroborates its hMC3R potency (EC 50 = 4.2 nM, E max = 91%) and demonstrates enhanced hMC4R potency (EC 50 = 0.048 nM, E max = 100%) (25)
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The results demonstrate that l-carnitine can be administered as a preventive intervention to reduce the reproductive damage caused by high-altitude hypobaric and hypoxic environments and improve semen quality in a rat model
