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Description
This study describes the contribution of elevated circulating LCN2 to cachexiaanorexia, potentially mediated through MC4R-expressing neurons in the hypothalamus, exemplifying a mechanism of bio-amplification

In addition to low L-carnitine (due to a heterozygote transporter mutation), elevated 3-methylhistidine was present, suggesting elevated muscle breakdown

Treatment with insulin resulted in higher presentation of LRP1 at the cell surface [73]

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