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Points to ponder on the role of polynucleotides in regenerative and aesthetic medicine: a systematic review

15 Because dysregulation of insulin signaling has been implicated in the pathogenesis of adult acne, it is thought that supplementation with the probiotic strain Lactobacillus rhamnosus SP1 (LSP1) normalizes skin expression of genes involved in insulin signaling and subsequently improves the appearance of adult acne

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A 2024 study identified the metabolite Ac-LKKTE as showing significantly greater wound-healing activity in fibroblast models than TB-500 alone (Rahaman et al.)
