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A landmark randomized, double-blind, placebo-controlled trial published in Gut investigated the use of L-Glutamine in patients who developed diarrhea-predominant Irritable Bowel Syndrome (IBS-D) following an acute enteric infection

Specifically, LDHB depletion impairs GSH synthesis and leads to hypersensitivity of KRAS -mutant cancer cells to ferroptosis inducers, which is causally linked to increased glutaminolysis and mitochondrial ROS

Furthermore, the pain and swelling in gout is caused by an inflammatory response, so the synovial fluid can also appear cloudy, yellow, and have a significant number of WBCS (usually mostly neutrophils), similar to the synovial studies of a septic joint

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