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Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide Contributes to Cardiac Dysfunction in Western Diet-Induced Obese Mice

The gut microbiota interacts with the host through the intestinal mucosal surface, and the function of the intestinal epithelial barrier is maintained through several functions of a well-balanced gut microbiota, such as the restoration of tight junction protein structure, mucin gene upregulation, and inhibition of epithelial cell binding with pathogenic bacteria

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