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While efficacy endpoints for weight loss in those trials were modest, the compound exhibited a favorable safety profile, supporting its later GRAS designation for food use
Lau et al., 2021)
Implicated specifically were increased angiogenesis, elevated vascular endothelial growth factor (VEGF) levels, upregulation of the early growth response (egr-1) gene, enhanced nitric oxide (NO) and NO-synthase (eNOS) stimulation, and counteraction of increased free radical formation [1]
