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The dose delivered to the body can be far higher than from a cream or tablet, since injected substances bypass digestion and the skin barrier and go straight into the tissues at full strength

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IDH-mutant cells are susceptible to ROS-induced damage In cases of disrupted metabolic pathways, like an impeded TCA cycle, it is crucial for the cell to obtain a TCA cycle-independent source for KG

Tran PV, Kennedy BC, Lien Y-C, Simmons RA, Georgief MK (2015) Fetal iron deficiency induces chromatin remodeling at the Bdnf locus in adult rat hippocampus