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Description
STIM2 regulates capacitive Ca 2+ entry in neurons and plays a key role in hypoxic neuronal cell death
10.15761/IMM.1000389 Lubos E, Loscalzo J, Handy DE (2011) Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities

5-Amino-1MQ is an oral NNMT (nicotinamide N-methyltransferase) inhibitor that works by blocking an enzyme that depletes cellular NAD+ and SAM

In particular, the depletion of glutathione has been proposed as an early event prior to the initiation of apoptosis by oxidants inducing the ROS production, while the supplementation of glutathione has the effect of preventing such apoptosis [15,16,18]
