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Human evidence is limited to three small pilot studies (fewer than 30 total subjects) covering interstitial cystitis, knee pain, and IV safety, none with placebo controls

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Thus, it appears important to evaluate vitamin B 12 status, as well as kidney function, in older individuals with elevated homocysteine levels prior to initiating homocysteine-lowering therapy

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10.1016/j.yexcr.2012.01.020

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An inhibitor is a compound that blocks this enzymes activity

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