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The epidermis and dermis interact cooperatively to maintain skin homeostasis, barrier function, and overall human health

Except for the regulation of melanocytes, keratinocytes will secrete cytokines, growth factors, and inflammatory mediators that can increase melanin production and/or stimulate melanin transfer to keratinocytes by melanocytes ( Up to now, more than 130 compounds have been identified in Epimedium species, including flavonoids, icarisides, and other kinds of compounds, such as essential oils, fatty acids, phytosterols, and polysaccharides

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