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Metabolites produced by gut microbiota may influence brain neurons, and PD patients often experience gastrointestinal dysfunction

doi: 10.1249/JSR.0000000000000729 115 KouXHanLLiXXueZZhouF

AXL-1717 is a non-ATP competitive IGF1R kinase inhibitor that has shown some promise and has orphan drug status for treatment of patients with relapsed malignant astrocytomas [62]

In addition, in multiple in vitro studies using animal and human GCs, quercetin treatment enhanced viability of GCs, reduced the percentage of early apoptotic cells, relieved deterioration in oocyte quality, and improved subsequent embryo development (Wang H et al., 2017