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By inhibiting NNMT, 5-Amino-1MQ increases cellular SAM and NAD+ levels, enhances NAD+ salvage pathway flux, activates SIRT-1, boosts oxidative phosphorylation (OXPHOS), and influences cellular energy homeostasis and epigenetic modifications

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When NNMT is active, it methylates nicotinamide (a form of vitamin B3), making it unavailable for conversion into NAD a crucial molecule for energy production and cellular repair
