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Furthermore, treatment with an AMPK agonist has been found to alleviate clinical symptoms, improve pathological changes, and reduce 24-h urinary protein levels in these patients [440]

Excess amounts excrete through urine without causing harm

After the cells were treated with 0.5, 1, 2, 3, 4 mM of ALA and/or 30 cisplatin for 30 h, 0.5 mg/mL of MTT solution was added to cell culture media, followed by incubation for 2 h at 33 C with 10% CO 2
