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We thank Christopher Koscher for his assistance with protein expression and purification and Florian Grebien for help with establishing the RPE-1 cell lines stably expressing p53 and p53 mutants

Further investigations are needed to examine how modifications by acrolein modulate the function of proteins and cellular processes

Chronic metabolic acidosis is due to the accumulation of the acidic compound 5-oxoproline

This helps explain why patients with extensive surgical trauma or prolonged ischemia often develop a systemic inflammatory response that parallels septic shock, even in the absence of infection ( Importantly, these pathways offer targets for intervention: blocking upstream mtDAMPs release or downstream receptors could blunt the harmful inflammation