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"The Effect of Artificial Sweeteners Use on Sweet Taste Perception and Weight Loss Efficacy: A Review." Nutrients , 2022

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The Therapeutic Goods Administration (TGA) in Australia granted it Generally Recognized As Safe (GRAS) status for use in foods at one point, but that classification does not transfer to injectable compounded preparations in the United States [2]

While the study establishes a compelling systemic role for SLC25A45 in fuel switching, important questions remain regarding the tissue-specific contributions of this pathway and how carnitine biosynthesis and utilization are differentially regulated across dietary, disease, and sexually dimorphic contexts