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With steady advancement of regulatory approval processes, DPP1 inhibitors are expected to become important treatment options for diseases such as bronchiectasis in the near future

In patients with impaired glucose tolerance and DPN, the staining patterns of sural nerves were similar but less intense compared with those found in patients with overt diabetes, indicating that ROS production and proinflammatory pathways are activated even before chronic hyperglycemia occurs [42]

In addition, we observed that the number of activated microglia/macrophages at the injury site in the CD38-deficient mice was significantly lower than that in the WT mice, while CD38 was expressed in brain microglia

doi: 10.1016/j.ijbiomac.2012.09.009