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2015;7(288):288ra277

This process often called inflammaging is associated with: Hair loss Arthritis Cardiovascular disease Insulin resistance Autoimmunity Neurodegeneration Accelerated biological aging MOTS-c appears to interact with pathways involved in: Oxidative stress Cellular inflammation Metabolic stress signaling This is why researchers are deeply interested in mitochondrial peptides for: Longevity science Regenerative medicine Anti-inflammatory wellness MOTS-c & Cardiovascular Health Mitochondrial dysfunction plays a major role in: Heart aging Vascular dysfunction Endothelial inflammation Metabolic cardiovascular disease Emerging research suggests MOTS-c may influence: Cellular energy regulation Oxidative stress pathways Metabolic cardiovascular adaptation Healthy mitochondrial signaling is increasingly recognized as essential for: Heart health Vascular aging Longevity MOTS-c & Bone Health Another emerging area of research is MOTS-c and musculoskeletal aging

For both conditions, on day 4, cell medium was removed and replaced with medium containing DMSO or 1 M Erastin2