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Oral mucosa has a rich vascular supply and lymphatic drainage, therefore, absorption from it can bypass intestinal and hepatic degradation leading to a high serum level which can be of therapeutic value

In a clinical study, the highest injectable dose of ixekizumab (150 mg) completely cleared the skin of approximately 40% of psoriasis patients by 12 weeks, with no serious adverse effects reported

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Remember, B12 is needed for this cell to mature, so with insufficient B12 megaloblasts accumulate in your bone marrow and large red cells called macrocytes appear in your blood