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In particular, GH hypersecretion leads to gigantism in childhood and acromegaly in adults, whereas congenital disruption of GH signaling causes short stature and in rare cases Laron syndrome

Jimmy made allowances for his symptoms at first, chalking them up to the physical demands of his job

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Overall, this relatively high-quality evidence demonstrates substantial overlap between proportions of patients expected to experience clinically significant improvement from PPS (21% to 56%) compared to from placebo treatment (13% to 49%)
