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This complex interplay between barrier integrity, immune response, and reproductive health underscores the importance of maintaining the BTB and managing inflammation to preserve male fertility ( 3 Release of systemic inflammatory factors and effects on distant organs Varicocele, as a leading cause of male infertility, is increasingly recognized to induce not only localized testicular inflammation but also a cascade of systemic inflammatory responses that extend beyond the reproductive tract ( Figure 2 )

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Genetic invalidation of Lp-PLA 2 as a therapeutic target: large-scale study of five functional Lp-PLA 2 -lowering alleles