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10.1371/journal.pone.0050999 PLoS ONE 38 CrunkhornS

Causes of Acanthosis Nigricans: Acanthosis nigricans is associated with a variety of underlying conditions and factors, including: Insulin Resistance : The most common cause of acanthosis nigricans is insulin resistance, a condition in which the bodys cells become less responsive to insulin, leading to elevated blood sugar levels

Dietary sugars and endogenous formation of advanced glycation endproducts: Emerging mechanisms of disease

Raman microscopy can extend reliable identification toward approximately 1 m and, under optimised conditions, may reach into the sub-micrometre range