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His efforts were ignored by the American government

A major cause of DNA damage

Therefore, interventions targeting the gut microbiota may increase the levels of BH4 in the body, which can be beneficial for human health, especially for patients with congenital biopterin deficiency

However, this work once again highlights the remarkable metabolic plasticity of tumour cellsa key aspect of cancer biologywhich allows them to adapt to adverse nutritional conditions and, in many cases, to develop therapy resistance