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Besides the simple explanation that with increasing age the average consumption of drugs is higher (including multiple medications) and the risk for an additional disease that could influence the manifestation of idiosyncratic DILI is greater in older patients, there are other reasons based on a mechanistic base

In addition, acetaminophen exposure itself induces increased CYP2E1, thus increasing the amount of NAPQI formed with each exposure to the drug.Posadas et al

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