glutathione s-transferase mu 1 function The role of S-transferases in human disease pathogenesis and their current inhibitors Glutathione S-transferase - Wikipedia
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Although the molecular mechanisms are not yet fully understood, calcification is now recognized as an active rather than passive and tightly regulated process, primarily driven by vascular smooth muscle cells (SMCs)

10.1016/j.cmet.2006.12.004 8 ArrudaM

Nature Rev Immunology

This is due to the fact that excess weight can lead to insulin resistance, which in turn causes the appearance of dark patches
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