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In the lungs, after entering in type II alveolar cells, SARS-CoV-2 infected cells become defective for surfactant production (Ghati et al., 2021) and release cytokines, like IL-8 among others, which in turn activate alveolar macrophages to release IL-1, IL-6, and TNF-, that induce natural killer and dendritic cell differentiation and macrophage M1 polarization, enhancing the proinflammatory response with increased vasodilation causing neutrophil and activated T cell influx from the capillaries into the alveolus, all leading to the cytokine storm (Carcaterra and Caruso, 2021

Correct diagnosis remains the key to correct treatment in PH (Flowchart 2) In most cases, echocardiography can be used to estimate sPAP using Doppler evaluation of tricuspid regurgitation or to identify findings that indicate a low, intermediate or high probability of PH

Leuk Lymphoma 11:207214

More extensive studies are needed to identify effective targets for PD patients, especially to protect the peritoneal membrane integrity and prevent EMT