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Increasing evidence suggests that mitochondria play a central role in aging and in neurodegenerative diseases, such as Alzheimers disease, Parkinsons disease, Huntingtons disease, amyotrophic lateral sclerosis, and Freidriech ataxia

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Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a potential therapeutic target for different kinds of pathologies including cancer, cardiovascular disease, respiratory disease, and other conditions