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Description
2023;29:S32S42
European Association for the Study of the Liver (EASL)
It should be noted that GCLM KO mice have systemic GSH deficiencies, ranging from 10 to 40% of normal levels depending on the tissue type 16
Differently, a marked depletion of GSH and ATP levels, accompanied by a profound increase in TBARS and ROS production, are associated with hepatocyte necrosis (Figure 4) [9]
