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When it becomes oxidized, it can break down yielding a large variety of compounds including a, -unsaturated aldehydes (Poli et al., 1987) These are toxic compounds because they can react with proteins in the cells, particularly at cysteine, lysine or histidine by either Michael addition to the carboncarbon double bond or by Schiff base formation at the carbonoxygen double bond (Esterbauer et al., 1991

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Based on these studies, it may be concluded that -synuclein is responsible for both the diminished activity of catalase and the increased formation of hydrogen peroxide, as substantiated by the increased oxidative stress markers in Parkinsons disease

10.3390/antiox12020517