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Description
As summarized in TABLE 5, at least seven different types of 5-HT receptor are expressed in the GI tract, and they are expressed on enteric neurons, extrinsic primary afferents, interstitial cells, smooth muscle cells, enteroendocrine cells, enterocytes, goblet cells, and immune cells, and some of these receptors exhibit constitutive activity
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Calling a format buccal or lipid-based does not demonstrate that an intact peptide reaches circulation in a meaningful amount
