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Similarly, ATOX1 is a copper chaperone that transfers copper and regulates the activity of the secretory pathway proteins ATP7A and ATP7B (Walker et al., 2002

To facilitate screening, a co-conversion strategy with dominant phenotypic roller marker was used 62

GPX4 structure, isoform, and function Structurally, GPX4 has a typical thioredoxin motif, comprised of four -helices and 7 b-strands located near the protein surface, 5 of which cluster together to form a central b-sheet