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Ineffective erythropoiesis leads to the formation of large, spherical erythrocytes, the lifespan of which is shortened due to their abnormal structure and lower resistance to mechanical damage and other environmental conditions

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Oxidative stress, which results from the imbalance between the production and neutralization of ROS, is also reported to be involved in a large number of pathological states, such as Alzheimers disease [30], Parkinsons disease [31], atherosclerosis [32], heart failure [33], myocardial infarction [34], and hepatic encephalopathy [35]

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