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The level of collagen hydrolysis product hydroxyproline suggested that H 2 O 2 accelerated collagen hydrolysis, while RGD-GHK prevented more collagen from degradation compared with the action of GHK, as shown in Figure 5A

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Recently, the endothelin converting enzyme-2, localized in endosomes, was shown to modulate recycling of DOR by degrading opioid peptides such as deltorphin II or the opioid peptide bovine adrenal medulla 22 (BAM22), a cleavage product of proenkephalin (Gupta et al., 2014)
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