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and a likely soluble form of CD38 present in the cytoplasm (Figure 1)

During catalysis, the removal of the nicotinamide moiety from -NAD is coupled with the formation of non-covalent enzyme-substrate intermediates such as E-ADPR or the less abundant E-cADPR

The subcutaneous route is used at much smaller doses than oral because a 100 mg injection would require two 50 mg vials and about 6 mL of liquid when each vial is mixed with 3.0 mL BAC water, which is too much for one subcutaneous site
