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In organisms that concentrate urea as an osmolyte and buoyancy factor, TMAO has been shown to restore proteins to their native structure and allow them to regain their enzyme function that has been lost because of the presence of urea [4,5]

Similarly, Wang et al

Preoperative interleukin-2 immunotherapy in pancreatic cancer: preliminary results

Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation