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A B12 shot is a quick intramuscular injection of vitamin B12 (cobalamin) that bypasses the stomach acid, liver metabolism, and intestinal absorption issues that limit oral B12 to roughly 1% bioavailability in most adults

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The most direct way to study a proposed lipolytic agent is in isolated fat cells or adipose explants, measuring glycerol and free-fatty-acid release into the medium, cAMP accumulation, and the phosphorylation state of HSL